Possible Complications

A number of common drug-related complications or adverse events have been reported for patients with hypogonadism in the general population. Adverse events for which there is evidence of association with testosterone administration include:1

  • erythrocytosis
  • acne and oily skin
  • detection of subclinical prostate cancer
  • growth of metastatic prostate cancer
  • reduced sperm production and fertility
     

Uncommon adverse events for which there is weak evidence of association with testosterone administration include:1

  • gynecomastia
  • male pattern balding (familial)
  • growth of breast cancer
  • induction or worsening of obstructive sleep apnea
     


Formulation-specific adverse events include:1

  • testosterone enanthate, cypionate or undecanoate (i.m. injections):
  • fluctuation in mood or libido
  • pain at injection site
  • excessive erythrocytosis (especially in older patients)
  • coughing episodes (after injection)