autoimmune production of antibodies against phospholipid, a component of the cell membrane.
a small protein that inhibits coagulation via inactivation of several enzymes of the coagulation system.
a fibrin degradation product (a small protein fragment containing two cross-linked D fragments of the fibrinogen protein that is present in the blood after a blood clot is degraded by fibrinolysis), the levels of which can be determined by a blood test to help diagnose thrombosis. A positive result can indicate thrombosis, but does not rule out other potential causes.
deep vein/venous thrombosis.
a coagulation factor that inhibits Factor IIa, and is a cofactor for heparin and dermatan sulphate.
hormone replacement therapy.
an abnormally increased tendency toward blood clotting (coagulation).
a measure of the time it takes for blood to clot compared with an average. This is an important measure in patients receiving anticoagulant therapy.
Lupus anticoagulant is an immunoglobulin that binds to phospholipids and proteins of the cell membrane. Despite the name, Lupus anticoagulant is actually a prothrombotic agent.
the inactive form of a protein involved in the coagulation process. Activated protein C is involved in the proteolysis of Factors V and VIII, thereby inhibiting coagulation.
protein S is a vitamin K-dependent protein found in the circulation either in its free form or complexed with complement protein C4b, whereby it acts as a cofactor in the inactivation of Factors V and VIII.
a cofactor that interacts with numerous components of the coagulation process, including Factor VIII and platelets.